BPC157 5mg

Description

BPC-157: A History and Overview

BPC-157, a synthetic peptide with 15 amino acids, has garnered attention for its potential healing and regenerative properties. Originally derived from a protein found in the human stomach, this peptide has been studied in various preclinical settings for its ability to accelerate the healing of a wide range of tissues, including muscles, tendons, ligaments, and the gastrointestinal tract.

BPC-157 Chemical Composition

• Chemical Structure: BPC-157 is a synthetic peptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. It is derived from a protein found in stomach acid.
• Synonyms: PENTADECAPEPTIDE; Bepecin; BPC 157; BPC-157 raw; peptide BPC157;peptides bpc157; GEPPPGKPADDAGLV;Pentadecapetide;Bpc-157 Peptides; BPC 157 USP/EP/BP
• CAS No: 137525-51-0
• Molecular Formula: The exact molecular formula of BPC-157 depends on its amino acid sequence, but it generally reflects the composition of its 15 constituent amino acids.
• Stability: BPC-157 is considered stable under various conditions and retains its potency in both acidic and basic pH levels, making it suitable for oral, topical, and injectable administration.
• Solubility: It is soluble in water and saline, allowing for versatile application methods.
• Mechanism of Action: Research suggests that BPC-157 promotes healing through multiple mechanisms, including enhancing the expression of growth hormone receptors, modulating nitric oxide (NO) production, and influencing the activity of genes involved in cytokine production, angiogenesis (formation of new blood vessels), and tissue regeneration processes.
• Healing Properties: Studies indicate that BPC-157 has a broad range of regenerative effects, beneficial for healing wounds, tendons, ligaments, muscle tissue, and even damaged nerves. It has been shown to accelerate wound healing and bone repair.
• Gastroprotective Effects: BPC-157 has shown significant efficacy in protecting and healing the gastrointestinal tract, making it a potential therapeutic candidate for conditions such as ulcers, inflammatory bowel disease (IBD), and gastritis.
• Cardiovascular Health: Preliminary research suggests that BPC-157 may have cardioprotective properties, potentially aiding in the treatment of vascular damage and promoting heart health.
• Neuroprotective Effects: BPC-157 may also exert neuroprotective effects, offering potential benefits in the treatment of brain injuries and neurodegenerative disorders.
• Safety Profile: While BPC-157 has been shown to be effective in various animal models, comprehensive safety and efficacy data in humans are limited, necessitating further research to fully understand its therapeutic potential and side effects.
• Legal Status and Availability: As of the last update, BPC-157 is not approved by regulatory agencies like the FDA for medical use. It is often sold as a research chemical not intended for human consumption.
• Shelf Life: 36 months
• Appearance: White lipolyzed powder puck.

Healing and Regenerative Properties

BPC-157 has shown promising results in animal studies, demonstrating capabilities to speed up the healing process of injuries to the skin, soft tissue, and internal organs. It is particularly noted for its effects on improving wound healing and reversing established arthritis in animal models. Furthermore, its potential in supporting systemic healing, particularly in contexts like bodybuilding and athletic performance where rapid recovery from injuries is desired, is of significant interest​​​​.

Dosage and Administration

The dosage of BPC-157 can vary, with athletic performance researchers often cycling doses in 4-week intervals, starting with 500-800 mcg daily injections and reducing to 200-500 mcg after the first two weeks. However, the appropriate dosage can depend on the individual’s condition, response, and guidance from healthcare professionals. For instance, suggested dosages based on body weight range from 110 μg for a 150lb person to 180 μg for a 250lb person, although there are currently no human pharmacokinetic studies to confirm these recommendations​​​​.

Risks and Side Effects

While BPC-157 is considered to have no known toxic side effects based on animal studies, the research in humans is still lacking, making its use experimental and necessitating caution. The most significant concerns involve the limited scope of clinical trials in humans, which leaves a gap in understanding the full spectrum of potential side effects and risks associated with its use​​.

Regulatory Status

It is crucial to note that BPC-157 is not approved for clinical use by any global regulatory authority and is listed by the World Anti-Doping Agency (WADA) as a prohibited substance under the category of unapproved substances. This classification highlights the need for further research to establish its safety, efficacy, and legal status for use in humans, especially athletes​​.

Conclusion

BPC-157 presents a promising area of research with its potential healing benefits. However, due to the experimental nature of this peptide and the lack of comprehensive human trials, those interested in its use must proceed with caution and seek professional medical advice. The ongoing research into BPC-157 will be crucial in determining its place in medical treatment and athletic performance enhancement.

Referenced Citations

1. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing – This study discusses the consistently positive and prompt healing effects of BPC 157 for various injury types. (https://pubmed.ncbi.nlm.nih.gov/31283706/)
2. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration – Explores BPC 157’s effects on tendon healing.
   (https://pubmed.ncbi.nlm.nih.gov/21030672/)
3. Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain – A small study suggesting BPC-157’s efficacy in relieving knee pain. (https://pubmed.ncbi.nlm.nih.gov/33071545/)
4. Modulatory effects of BPC 157 on vasomotor tone and the signaling pathways in vascular smooth muscle – Investigates how BPC 157 regulates vasomotor tone and related signaling.(https://pubmed.ncbi.nlm.nih.gov/31201964/)
5. BPC 157 and Standard Angiogenic Growth Factors: A Comparative Study on Healing and Angiogenesis in Muscle, Tendon, Ligament, and Bone Injuries – Compares BPC 157’s healing effects with other angiogenic factors. (https://pubmed.ncbi.nlm.nih.gov/31749639/)
6. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts – Focuses on BPC 157’s effect on tendon fibroblasts and growth hormone receptor expression. (https://pubmed.ncbi.nlm.nih.gov/25415472/)
7. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract – Discusses BPC 157 as a therapy for various gastrointestinal conditions.  (https://pubmed.ncbi.nlm.nih.gov/21485787/)
8. Pentadecapeptide BPC 157 and the central nervous system – Reviews BPC 157’s effects on central nervous system disorders. (https://pubmed.ncbi.nlm.nih.gov/34271771/)
9. Stable Gastric Pentadecapeptide BPC 157 as Useful Agent for Myocardial Infarction, Heart Failure, Pulmonary Hypertension, and Thrombosis Prevention – Examines BPC 157’s potential in treating heart-related conditions. (https://pubmed.ncbi.nlm.nih.gov/33485184/)
10. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing – Discusses BPC 157’s effectiveness in wound healing and its potential to counteract bleeding disorders.(https://pubmed.ncbi.nlm.nih.gov/30741583/)