GHK-Cu 20mg

Description

GHK-Cu: A History and Overview

GHK-Cu, a naturally occurring copper complex first identified in human plasma and subsequently found in saliva and urine, has emerged as a powerful peptide with a wide range of therapeutic benefits. This tripeptide, consisting of glycyl-L-histidyl-L-lysine copper, exhibits a high affinity for copper ions, which play a crucial role in various bodily functions​​.

GHK-Cu Chemical Composition

• Chemical Structure: GHK-Cu consists of the tripeptide Glycyl-L-Histidyl-L-Lysine (GHK) bound to a copper ion (Cu2+). The binding of copper ion enhances the biological activities of the GHK peptide.
• Synonyms: [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper;Ghk-Cu/AHK-CU;Copper tripeptide (GHK-Cu);Prezatide copper,[N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper;tripeptide/GHK-Cu;Copper peptide, GHK-Cu, Copper tripeptide-1;GHK Copper;GHK.CU.HAC
• CAS No: 89030-95-5
• Molecular Formula: The molecular formula for GHK-Cu is C14H24N6O4Cu, reflecting the composition of the peptide and the copper ion.
• Stability: GHK-Cu is relatively stable under standard storage conditions, though it should be protected from light and stored at a low temperature to maintain its activity. The copper complexation protects the peptide from degradation.
• Solubility: GHK-Cu is soluble in water and aqueous buffers, facilitating its application in various formulations, including topical creams, serums, and injectable solutions.
• Mechanism of Action: GHK-Cu promotes healing and tissue repair by stimulating collagen and glycosaminoglycan synthesis, modulating the expression of numerous genes associated with antioxidant defense, immune response, cell growth, and angiogenesis. It also plays a role in attracting immune cells to sites of injury.
• Therapeutic Use: GHK-Cu is used in cosmetic products for skin rejuvenation, anti-aging treatments, and improving skin elasticity and firmness. It is also researched for its potential in wound healing, hair growth promotion, and anti-inflammatory applications.
• Efficacy: Studies have shown GHK-Cu to enhance wound healing, stimulate collagen production, and reduce fine lines and wrinkles. It has also been found to improve hair transplant success and stimulate hair growth.
• Side Effects: GHK-Cu is generally considered safe for topical use with a low risk of irritation or adverse effects. However, sensitivity or reactions can occur, particularly in individuals with a copper allergy.
• Safety Profile: The compound has a good safety profile when used in appropriate concentrations in cosmetic and therapeutic formulations. Injectable forms should be used under medical supervision to avoid potential complications.
• Legal Status and Availability: GHK-Cu is available in cosmetic products and for research purposes. It is not classified as a pharmaceutical drug but as a cosmetic ingredient or research chemical in most regions.
• Shelf Life: 36 months
• Appearance: White lipolyzed powder puck

Mechanism of Action

GHK-Cu’s mechanism of action is multifaceted, impacting several pathways due to its peptide sequence and the biological activities of copper. It acts as a chemoattractant for immune cells at tissue injury sites, promoting proteins that stimulate growth and repair. It also enhances the production of critical components like collagen, elastin, and glycosaminoglycans, vital for tissue repair and maintenance​​. Additionally, GHK-Cu has been found to stimulate collagen synthesis by chondrocytes, supporting bone growth, and plays a role in angiogenesis, essential for tissue survival​​.

Therapeutic Benefits

The benefits of GHK-Cu span across skin rejuvenation, wound healing, hair growth, anti-inflammatory effects, and even potential anti-cancer properties. It tightens loose skin, improves elasticity, reduces fine lines and wrinkles, and reverses thinning of aged skin, making it a valuable agent in skincare​​​​. Studies have shown its efficacy in wound healing by stimulating cell proliferation, increasing collagen synthesis, and activating fibroblasts and mast cells​​. Moreover, it’s used in anti-aging cosmetics for its firming and anti-wrinkle activity​​.

Dosage and Forms

GHK-Cu is available in various forms, including injectables, creams, serums, and foams, catering to different therapeutic needs. The peptide is considered safe across a broad range of dosages, and its application method varies depending on the target area, whether it’s for facial skin, scalp, or wounds​​.

Legal Status and Recommendations

While GHK-Cu has shown promising results in research and cosmetic applications, it has not been approved by the FDA for medical use. It’s primarily recommended for individuals seeking to improve skin health, reduce aging signs, or accelerate wound healing. Before starting any new treatment, consulting with a healthcare professional is advised to ensure safety and effectiveness​​.

GHK-Cu’s potential in improving lung health, fighting hair loss, and even aiding in nerve regeneration highlights its versatility and promising future in therapeutic applications​​. Its ability to modulate copper levels and interact with cellular receptors offers a unique approach to addressing a variety of health conditions, underscoring the importance of ongoing research to fully unlock its therapeutic potential​​.

Referenced Citations

1. Epigenetic Mechanisms Activated by GHK-Cu Increase Skin Collagen Density – Practical Dermatology. (https://www.practicaldermatology.com)
2. Case Studies of the Peptide GHK-Cu: Exploring Therapeutic Applications – Peptides. (https://www.ptides.com)
3. YUVAN RESEARCH’s novel formulation of GHK-Cu provides greater stability – EurekAlert!. (https://www.eurekalert.org)
4. New Biotinylated GHK and Related Copper(II) Complex: Antioxidant and Antiglycant Properties In Vitro against Neurodegenerative Disorders – MDPI Molecules. (https://www.mdpi.com)
5. GHK Cu: Structure And Mechanism Of Action – Sports Technology Labs. (https://www.sportstechnologylabs.com)
6. Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application – PubMed. (https://www.ncbi.nlm.nih.gov)
7. Intranasal GHK peptide enhances resilience to cognitive decline in mice – PubMed. (https://www.ncbi.nlm.nih.gov)
8. Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation – Wiley Online Library. (https://onlinelibrary.wiley.com)
9. The impact of palmitoyl glycyl-histidyl-lysine on phospholipid model membranes – ScienceDirect. (https://www.sciencedirect.com)
10. Thermodynamically stable ionic liquid microemulsions pioneer pathways for GHK-Cu peptide delivery – PubMed. (https://www.ncbi.nlm.nih.gov)