Epithalon 10mg

Description

Epithalon: A History and Overview

Epithalon, a synthetic peptide derived from the naturally occurring epithalamin found in the pineal gland, has garnered attention for its potential anti-aging benefits. This tetrapeptide, composed of alanine, glutamic acid, aspartic acid, and glycine, is celebrated for its ability to upregulate telomerase activity, leading to telomere elongation and potentially slowing down the aging process​​​​.

Epithalon Chemical Composition

• Chemical Structure: Epithalon is a tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly.
• Synonyms: Epitalon;Epithalon;Glycine, L-alanyl-L-a-glutamyl-L-a-aspartyl-;L-alanyl-L-alpha-glutamyl-L-alpha-aspartylglycine;9: PN: WO02090380 PAGE: 55 claimed protein;L-Alanyl-L-α-glutamyl-L-α-aspartylglycine;Epithalon, Epithalon Tetra Peptide;EpithalonAcetate
• CAS No: 307297-39-8
• Molecular Formula: The molecular formula for Epithalon is C14H22N4O9, which reflects its composition of carbon (C), hydrogen (H), nitrogen (N), and oxygen (O) atoms.
• Stability: Epithalon is relatively stable at room temperature but is best stored in lyophilized form at -20°C or colder to maintain its potency over time. Once reconstituted with sterile water or saline, it should be used within a short period and stored in the refrigerator.
• Solubility: It is soluble in water and saline, facilitating its administration through subcutaneous or intravenous injections.
• Mechanism of Action: Epithalon is believed to act by stimulating the activity of telomerase, an enzyme that catalyzes the elongation of telomeres. Telomeres are the protective caps at the ends of chromosomes that shorten with each cell division, and their length is associated with cellular aging.
• Therapeutic Use: Research has explored Epithalon’s potential in extending life span, preventing age-related diseases, improving skin health, and regulating circadian rhythms. However, most studies are preclinical or conducted in small human trials.
• Efficacy: Some studies suggest that Epithalon can increase telomere length and potentially enhance lifespan and healthspan in model organisms. Evidence in humans is limited but points towards possible benefits in terms of biomarkers of aging and disease prevention.
• Side Effects: There is limited information on the side effects of Epithalon due to the relatively small number of human studies. In available research, it has been generally well-tolerated.
• Safety Profile: The long-term safety and potential side effects of Epithalon in humans are not well-established, necessitating further research to understand its implications fully.
• Legal Status and Availability: Epithalon is not approved by the FDA or other regulatory agencies for medical use. It is available through various online sources as a research peptide, intended for scientific study and not for human consumption.
• Shelf Life: 36 months
• Appearance: White lipolyzed powder puck

The Science Behind Epithalon

The mechanism of action of Epithalon revolves around the activation of telomerase, an enzyme responsible for adding DNA sequence repeats to the ends of DNA strands in the telomere regions. This activity is crucial because telomeres protect chromosome ends but shorten with each cell division, leading to cellular aging. By elongating telomeres, Epithalon may help maintain cell viability and extend cell life, offering a promising avenue for anti-aging research​​​​.

Clinical Trials and Research Findings

Research into Epithalon has spanned in vitro studies, animal models, and limited human trials, consistently highlighting its potential to extend lifespan and combat age-related diseases. Notably, studies have shown Epithalon’s capacity to increase telomerase activity in human somatic cells, leading to telomere elongation. Animal studies have further supported its longevity benefits, with treated subjects showing significant lifespan extensions and reduced tumor incidence compared to controls​​​​.

Moreover, human clinical trials, particularly those conducted in Russia, have demonstrated promising outcomes regarding overall survival and mortality reduction amongst the elderly. These studies suggest that Epithalon could decelerate aging of the cardiovascular system, improve physical endurance, and enhance the circadian rhythm of melatonin production​​.

Potential Benefits and Uses

Epithalon’s benefits extend beyond merely anti-aging. It has been associated with improved cell health, reduced risk of neurodegenerative diseases, antioxidant effects, and enhanced immune function. Additionally, it may improve sleep quality by regulating melatonin production, an essential factor for maintaining the body’s biological clock​​​​.

Considerations and Future Outlook

While Epithalon presents a fascinating profile with its anti-aging and health-promoting effects, it’s crucial to approach its use with caution due to the lack of extensive human clinical trials and FDA approval. The existing research, primarily conducted by its discoverers, highlights its potential, yet broader and more diversified studies are needed to fully understand its effects and safety profile​​.

Epithalon stands as a beacon of hope in the quest for longevity and healthy aging, embodying the potential to unlock new pathways for extending human lifespan and enhancing life quality. As research continues to evolve, Epithalon may one day become a cornerstone of anti-aging therapy, offering a scientific fountain of youth that could transform our approach to aging and disease prevention.

Referenced Citations

1. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis in Human Gingival Mesenchymal Stem Cells (https://pubmed.ncbi.nlm.nih.gov/31425105/)
2. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells (https://pubmed.ncbi.nlm.nih.gov/12937682/)
3. Peptides and Ageing: Effects of Epithalon on Cell Cycle Regulation and Telomerase Activity
   (https://pubmed.ncbi.nlm.nih.gov/25826983/)
4. Effect of Epitalon on Biomarkers of Aging, Life Span and Spontaneous Tumor Incidence in Mice (https://pubmed.ncbi.nlm.nih.gov/12537670/)
5. Studies of the Effects of Vilon and Epithalon on Gene Expression in Heart of Mice
   (https://pubmed.ncbi.nlm.nih.gov/16224605/)
6. Epitalon Protects Against Post-Ovulatory Aging-Related Damage in Reproductive Cells
   (https://pubmed.ncbi.nlm.nih.gov/26345467/)
7. Peptide Promotes Overcoming of the Division Limit in Human Somatic Cells
   (https://pubmed.ncbi.nlm.nih.gov/14501183/)
8. Effects of Peptides on Proliferative Activity of Retinal and Pigmented Epithelial Cells
   (https://pubmed.ncbi.nlm.nih.gov/15344536/)
9. Peptide Epitalon Activates Chromatin in Old Age
   (https://pubmed.ncbi.nlm.nih.gov/15204068/)
10. Effect of Epithalon on Age-Specific Changes in the Retina in Rats with Hereditary Pigmentary Dystrophy (https://pubmed.ncbi.nlm.nih.gov/15517816/)