MOTS-c 5mg

Description

MOTs-C: A History and Overview

MOTS-c 5mg, or Mitochondrial-Derived Peptide MOTS-c, has gained prominence in the realm of aging and metabolic research for its unique properties and potential therapeutic applications. This mitochondrial-encoded peptide plays a significant role in metabolic regulation, energy homeostasis, and the modulation of cellular stress responses, positioning it as a key player in the fight against age-related diseases and metabolic disorders.

MOTs-C Chemical Composition

• Chemical Structure: MOTS-c is a short peptide consisting of 16 amino acids, with the sequence Met-Gln-Arg-Ala-Leu-Asp-Leu-Leu-Arg-Leu-Leu-Gln-Gly-Leu-Phe-Arg.
• Synonyms: MOTS-c;L-Arginine, L-methionyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-α-glutamyl-L-methionylglycyl-L-tyrosyl-L-isoleucyl-L-phenylalanyl-L-tyrosyl-L-prolyl-L-arginyl-L-lysyl-L-leucyl-;MOTS-C acetate; Cosmetic Peptide Mots-C;MOTS-c POWDER
• CAS No: 1627580-64-6
• Molecular Formula: The molecular formula for MOTS-c is indicative of its amino acid composition, which includes carbon (C), hydrogen (H), nitrogen (N), oxygen (O), and sulfur (S) atoms. The precise formula is C71H112N20O22S1.
• Stability: MOTS-c is stable at -20°C in lyophilized form. Once reconstituted, it should be stored at 4°C and used within a short period to maintain stability and activity.
• Solubility: It is soluble in water and aqueous buffers, making it suitable for experimental studies involving injection or in vitro applications.
• Mechanism of Action: MOTS-c targets multiple metabolic pathways, primarily acting in the cytoplasm to regulate insulin sensitivity, enhance glucose utilization, and promote metabolic flexibility. It activates AMP-activated protein kinase (AMPK), a key energy sensor in cells, leading to improved mitochondrial function and energy homeostasis.
• Therapeutic Potential: Research has highlighted its potential in treating metabolic disorders such as obesity, type 2 diabetes, and age-related metabolic decline. MOTS-c has also been shown to improve exercise endurance and promote weight loss in animal models.
• Efficacy: Studies in mice have demonstrated that MOTS-c administration can reduce obesity-induced insulin resistance, protect against diet-induced obesity, and enhance metabolic health. Its effects in humans are the subject of ongoing research.
• Side Effects: As of the last update, detailed information on the side effects of MOTS-c in humans is limited due to the relatively early stage of research. Animal studies have not reported significant adverse effects.
• Safety Profile: The safety profile of MOTS-c in humans remains to be fully established through clinical trials. However, early-stage animal studies suggest it is well-tolerated.
• Legal Status and Availability: MOTS-c is primarily available for research purposes and is not yet approved by regulatory agencies like the FDA for clinical use. Its use in humans is limited to clinical studies and trials.
• Shelf Life: 36 months
• Appearance: White lipolyzed powder puck

Discovery and Mechanism of Action

MOTs-C was discovered as part of a broader investigation into the signaling roles of small peptides encoded by mitochondrial DNA, which was traditionally viewed primarily as the powerhouse of the cell. Unlike other mitochondrial peptides that have been studied, MOTs-C is unique because it is encoded within the mitochondrial DNA but acts primarily in the cytoplasm and affects metabolic processes throughout the body.

The primary mechanism through which MOTs-C exerts its effects is by enhancing insulin sensitivity and regulating metabolic pathways, including glucose and lipid metabolism. Research has shown that MOTs-C can mimic the effects of caloric restriction, a well-known intervention to extend lifespan and reduce the risk of age-related diseases. By activating AMPK and modulating the insulin signaling pathway, MOTs-C helps maintain metabolic balance and supports cellular resilience against stress (Lee et al., 2015; Kim et al., 2018).

Potential Therapeutic Applications

The implications of MOTs-C research are vast, with potential therapeutic applications in the treatment of metabolic disorders such as type 2 diabetes, obesity, and insulin resistance. Additionally, its role in regulating metabolism and enhancing insulin sensitivity suggests that MOTs-C could be leveraged to improve age-related metabolic decline and extend healthy lifespan.

Emerging studies also indicate that MOTs-C may play a role in preventing the development of certain types of cancer and neurodegenerative diseases, further underscoring its potential as a multifaceted therapeutic agent (Zhang et al., 2016; Cobb et al., 2016).

Challenges and Future Directions

Despite the promising findings associated with MOTs-C, there are several challenges to overcome before its therapeutic potential can be fully realized. The stability and bioavailability of MOTs-C when administered exogenously, the optimization of dosing regimens, and the elucidation of its mechanisms of action in various tissues and disease states are areas that require further investigation.

Future research directions will likely focus on the development of MOTs-C analogs with enhanced pharmacological properties, the exploration of its therapeutic potential in various disease models, and clinical trials to assess its efficacy and safety in humans.

Conclusion

MOTs-C represents an exciting frontier in mitochondrial biology, offering new insights into the intricate relationship between mitochondria and systemic metabolic health. As research progresses, MOTs-C and its analogs may offer novel therapeutic avenues for the management and treatment of a wide range of metabolic disorders, contributing to healthier aging and improved quality of life.

Referenced Citations

1. MOTS-c as an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis explores how MOTS-c treatment improves physical performance and metabolic health in mice, demonstrating its potential to counteract age-related physical decline. (https://www.nature.com/articles/s41467-020-20790-0)
2. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism, and aging discusses the role of MOTS-c in mediating communication between mitochondrial and nuclear genes, highlighting its significance in stress response, metabolism, and aging processes. (https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-03885-2)
3. A promising mitochondrial-derived peptide for therapeutic exploitation reviews the therapeutic potentials of MOTS-c against various diseases, emphasizing its development in synthetic biology and potential applications in treating metabolic disorders and aging. (https://pubmed.ncbi.nlm.nih.gov/36761202/)
4. MOTS-c, the most recent mitochondrial-derived peptide in human aging and age-related diseases examines the biological effects of MOTS-c on age-related diseases like diabetes, cardiovascular diseases, and Alzheimer’s, underscoring its potential as a therapeutic agent in mitigating age-associated disorders. (https://www.mdpi.com/1422-0067/23/19/11991)
5. The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats shows that exogenous MOTS-c injection increases myocardial MOTS-c content and activates AMPK, suggesting a synergistic effect of MOTS-c treatment and exercise on myocardial function. (https://www.nature.com/articles/s41598-021-99568-3)Shorten with AI